Sequential ADP-ribosylation pattern of nucleosomal histones. ADP-ribosylation of nucleosomal histones
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چکیده
منابع مشابه
ADP-ribosylation of core histones and their acetylated subspecies.
ADP-ribosylation of core histones was investigated in isolated nuclei of Physarum polycephalum. Core histone species differed in the mode of modification. Whereas ADP-ribosylation of H2A and H2B is sensitive to inhibition by 3-methoxybenzamide, as with most other nuclear acceptor proteins, the modification of H3 and H4 is not inhibited. Cleavage experiments with hydroxylamine indicate a carboxy...
متن کاملPoly(ADP-ribosylation) protects maternally derived histones from proteolysis after fertilization.
Fertilization in sea urchins is followed by the replacement of sperm-specific histones by cleavage-stage histone variants recruited from maternal stores. Such remodelling of zygote chromatin involves a cysteine proteinase that degrades the sperm-specific histones in a selective manner, leaving the maternal cleavage-stage histone variants intact. The mechanism that determines the selectivity of ...
متن کاملReversing ADP-ribosylation
The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
متن کاملSerine is a new target residue for endogenous ADP-ribosylation on histones
ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type ...
متن کاملADP-ribosylation of nuclear proteins.
ADP-ribosylation can be defined as the postsynthetic modification of protein by the covalent attachment of the ADP-ribose moiety of NAD+. ADP-ribosylation of elongation-factor Tu is responsible for the inhibition of protein synthesis by both diptheria and Pseudomonas aeroginosa toxins (Hilz & Stone, 1976). The activation of membrane adenylate cyclase by cholera toxin is thought to occur by ADP-...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1985
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1985.tb08650.x